Murillo remains with Diego and Juan for three years until he finally returns to Seville. In 1649, the King again commissions Diego to journey to Italy to collect paintings and statues to beautify the royal museums. As before, Diego takes Juan with him. They sail from Malaga, Spain. A winter storm roils the sea, and Diego again falls ill. As Diego tries to cross the swaying cabin, he falls into the bulkhead, severely injuring his right hand. Though Juan tends him, when they finally land in Genoa, Diego’s hand is swollen and painful. As Diego distrusts Italian surgeons, Juan must care for Diego’s hand alone. Juan binds the hand in a hot cloth and directs Diego to drink broth and wine. When Diego’s hand finally heals, he prompts Juan to request something in return for his care. However, Juan defers the promise and wishes only for Diego’s good health.

Diego and Juan travel through Italy, collecting artwork for the King. The Italian countryfolk impress them with their generosity, and Diego often pauses to paint a scene. When a storm descends, Diego’s hand once again swells, causing fever. He worries that if his hand does not heal, his career will flounder.