Content Warning: This section of the guide contains descriptions of violence and suicide.

In 1566, Ebrima and Carlos live prosperous lives as successful iron-makers in Antwerp. The city is divided between Protestants and Catholics, and religious tensions are high after the Massacre of Wassy. Ebrima, who secretly practices traditional African spirituality, fears losing his new life. At an open-air meeting in Antwerp, Ebrima discreetly counts the Protestants and realizes their growing influence. Carlos mentions his commission of a painting for Antwerp's Cathedral of the miracle of turning water into wine. Despite scrutiny, Ebrima and Carlos navigate their complex religious landscape, with Ebrima's stepson, Matthus, questioning the Catholic Church. The atmosphere at the meeting is peaceful until the high inquisitor, Pieter Titelmans arrives. Ebrima refuses to betray his neighbors to Titelmans.

The unveiling of the painting is interrupted by Titelmans, who accuses one of the families of being Protestants. The daughter, Drike, confirms that she is, and she is arrested. Despite pleas for her to recant, she faces execution by burning. She arrives dressed in white, as a martyr. Ebrima incites a riot to save her. The family leaves Antwerp, and later a Protestant mob storms priests' homes and the church.